Interleukin-8 induction and adhesion of the coccoid form of Helicobacter pylori

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Interleukin-8 induction and adhesion of the coccoid form of Helicobacter pylori.

To determine the pathological significance of the coccoid form of Helicobacter pylori, its adhesion to and induction of secretion of interleukin-8 (IL-8) by gastric epithelial (MKN45) cells were studied. By flow cytometry, the adhesion of the coccoid form to MKN45 cells was significantly lower than that of the helical form. The monoclonal antibody A20 recognising lipopolysaccharide of H. pylori...

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Is the coccoid form of Helicobacter pylori viable?

Helicobacter pylori was grown on solid medium for up to 5 weeks. Morphological conversion from spiral to coccoid forms began after 7 days incubation under microaerophilic conditions. Similar to the exponential cultures, the ageing bacteria produced alkaline phosphatase, acid phosphatase, leucine arylamidase and naphthol-AS-beta 1-phosphohydrolase, although there was a reduction in the levels of...

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Methods for Detecting the Environmental Coccoid Form of Helicobacter pylori

Helicobacter pylori is recognized as the most common pathogen to cause gastritis, peptic and duodenal ulcers, and gastric cancer. The organisms are found in two forms: (1) spiral-shaped bacillus and (2) coccoid. H. pylori coccoid form, generally found in the environment, is the transformed form of the normal spiral-shaped bacillus after exposed to water or adverse environmental conditions such ...

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Coccoid forms of Helicobacter pylori.

To the Editor-Eaton et al. [1] recently described experiments with coccoid Helicobacter pylori in gnotobiotic piglets. This interesting study examined the colonization and the reversion from coccoid to bacillary H pylori within 2 weeks of inoculation. Piglets colonized with bacillary H pylori had more severe gastritis 2 weeks after inoculation than did those sacrificed 1 week after inoculation....

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Coccoid form of Helicobacter pylori as a morphological manifestation of cell adaptation to the environment.

After characterization of preferred conditions for Helicobacter pylori survival in the sessile state, it was observed that the bacterium transforms from spiral to coccoid under mild circumstances, whereas under extreme ones it is unable to undergo shape modification. This strongly supports the view that transformation into the coccoid form is an active, biologically led process, switched on by ...

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ژورنال

عنوان ژورنال: Journal of Medical Microbiology

سال: 2002

ISSN: 0022-2615,1473-5644

DOI: 10.1099/0022-1317-51-4-295